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Hat is unique to the individual, but there is an opportunityHat is unique to the individual, but there is an opportunity going forward for epidemiologic and other studies to evaluate these combined exposures more comprehensively. That said, given the difference between observed exposures as measured by urine levels and estimated urine levels from regulatory or ToxCast values indicates that e
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Ytes. Conclusions: These results demonstrate that in RBA-1 cells, activation of c-Jun/AP-1 by a CaMKII-dependent PI3K/ Akt-JNK activation mediated through transactivation of PDGFR is essential for up-regulation of MMP-9 and cell migration induced by LTA. Understanding the regulatory mechanisms underlying LTA-induced MMP-9 expression and functional changes in astrocytes may provide a new therapeuti
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Ytes. Conclusions: These results demonstrate that in RBA-1 cells, activation of c-Jun/AP-1 by a CaMKII-dependent PI3K/ Akt-JNK activation mediated through transactivation of PDGFR is essential for up-regulation of MMP-9 and cell migration induced by LTA. Understanding the regulatory mechanisms underlying LTA-induced MMP-9 expression and functional changes in astrocytes may provide a new therapeuti
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That in vitro bioassay results may not translate to in vivoThat in vitro bioassay results may not translate to in vivo effects, the combined evidence indicates it is highly implausible that exposures to 2,4-D and/or MCPA are associated with a risk of developing NHL or other lymphohematopoietic cancers. However, exposures and potential impacts are considered only for exposure to 2,4-D and MCP
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