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Nucleation clusters. In calcium phosphate solution, the presence of amelogenin stabilized small particles, aggregates with two or three particles and larger aggregates (pre-nucleation clusters). While needle shaped particles of hydroxyapatite were eventually formed, the amorphous aggregates were stabilized by amelogenin, leading to the statement that amelogenin inhibited (retarded) mineralization
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Like sibling children, they share common heritage (genes) and some structural homology, often appearing to play different roles in regulating biomineralization in various states of health and disease of dentin and bone (Table 2). All bind to and regulate cell differentiation via different factors [81]. They all have numerous repeat sequences, most are charged. To illustrate, we developed a PERLbas
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Nucleation clusters. In calcium phosphate solution, the presence of amelogenin stabilized small particles, aggregates with two or three particles and larger aggregates (pre-nucleation clusters). While needle shaped particles of hydroxyapatite were eventually formed, the amorphous aggregates were stabilized by amelogenin, leading to the statement that amelogenin inhibited (retarded) mineralization
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An N-terminus with small acidic motif (DSpSpEE) that is also found in SIBLING proteins [65]. When solubilized, statherin has a random coil conformation. When bound to HA, it takes on a more alpha-helical structure exposing a bacterial binding site [63], leading to bacterial entrapment. Another example is the role of the IDP, DMP1, in preventing kidney and cardiovascular calcification. The double k
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Ated subunits (Table 1). Live attenuated vaccines currently available on the marketAted subunits (Table 1). Live attenuated vaccines currently available on the market include those against measles, mumps, rubella, varicella, influenza, rotavirus, and smallpox. Most of them are formulated as dry solids. Commercially available killed or inactivated vaccines, toxoids and subunit vaccines includ
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Like sibling children, they share common heritage (genes) and some structural homology, often appearing to play different roles in regulating biomineralization in various states of health and disease of dentin and bone (Table 2). All bind to and regulate cell differentiation via different factors [81]. They all have numerous repeat sequences, most are charged. To illustrate, we developed a PERLbas
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Larreal-RamirezPagecations and anions [62]; the formation of such chains could also be true of the calcium phosphate prenucleation clusters. 2.2 Pathologic Calcification: Role of IDPs Calcifications occurring in unwanted places ?the aorta, salivary glands and soft tissues, are all associated with IDPs. To illustrate, salivary stones occur when mucins, such as statherin, an un-folded protein [63],