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Idence). A E use: All-cause (2 studies): Both showed non-significant reduction (RR 0.64, 95 CI 0.31 to 1.33). COPD-specific (1 study): Significant reduction (RR 0.59, 95 CI 0.43 to 0.81). Admissions (7 studies): Mixed results. Intervention was associated with a reduction in admissions in older patients and those with higher baseline morbidity. Costs (11 studies): 3 performed full economic analys