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To 10.65 at week 8 and maintained through the rest of the year, while for those on venlafaxine XR the HAM-A score reduced just to 12.80. Moreover, pregabalin also allowed patients to spend more time in a better health state: during one year, the number of weeks with no or minimal GAD was estimated to be 12.9 for pregabalin and 3.8 for venlafaxine XR. Concerning the primary measure of this analysis
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Ebellum, and ventral midbrain of rats following treatment with intraperitoneal injected or orally drinking with aluminum chloride [26]. The results of the present study indicated that administration of high concentration AlCl3 induced higher levels of Al accumulation in the brain stem. Consistent with previous studies on adult rats, distribution of Al mainly occurred in 3 specific areas in neonata
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Y is consistent with the haploinsufficient effect of the gene observed in our mouse KO model. Indeed, mice hetero- or homozygous on the Tusc2 deletion shared similar immunological and tumorigenic phenotypes at comparable frequencies. These data suggest that even partial loss of the TUSC2 dosage is sufficient to trigger pathological inflammation and increase susceptibility to cancer [15]. We consid
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Ytes. Conclusions: These results demonstrate that in RBA-1 cells, activation of c-Jun/AP-1 by a CaMKII-dependent PI3K/ Akt-JNK activation mediated through transactivation of PDGFR is essential for up-regulation of MMP-9 and cell migration induced by LTA. Understanding the regulatory mechanisms underlying LTA-induced MMP-9 expression and functional changes in astrocytes may provide a new therapeuti
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Ytes. Conclusions: These results demonstrate that in RBA-1 cells, activation of c-Jun/AP-1 by a CaMKII-dependent PI3K/ Akt-JNK activation mediated through transactivation of PDGFR is essential for up-regulation of MMP-9 and cell migration induced by LTA. Understanding the regulatory mechanisms underlying LTA-induced MMP-9 expression and functional changes in astrocytes may provide a new therapeuti
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Ey rely on the resource consumption pattern estimated through the expert panel, the incremental costeffectiveness ratios would be 29,400 and 85.Sensitivity analysisOne-way deterministic sensitivity analysis was performed on the time horizon, assuming 8 weeks and 24 weeks; on the utility values considered, evaluating the impact of using the ones obtained on the PEACE study (0.83 for HAM-A score 9;
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A recurrentPage 8 of(page number not for citation purposes)Molecular Cancer 2009, 8:http://www.molecular-cancer.com/content/8/1/Table 4: Differentially expressed genes common for TUSC2-expressing MPM cells and clinical tumor specimens.Fold change and direction in TUSC2transfected MPM cells versus control 1 2 3 4 5 6 7 8 9 -8.04 -4.51 -4.10 -3.90 -3.64 -3.14 -3.08 -2.92 -2.Fold change and direction
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A recurrentPage 8 of(page number not for citation purposes)Molecular Cancer 2009, 8:http://www.molecular-cancer.com/content/8/1/Table 4: Differentially expressed genes common for TUSC2-expressing MPM cells and clinical tumor specimens.Fold change and direction in TUSC2transfected MPM cells versus control 1 2 3 4 5 6 7 8 9 -8.04 -4.51 -4.10 -3.90 -3.64 -3.14 -3.08 -2.92 -2.Fold change and direction